Many Phenotypes Without Many False Discoveries: Error Controlling Strategies for Multitrait Association Studies
نویسندگان
چکیده
منابع مشابه
Many Phenotypes Without Many False Discoveries: Error Controlling Strategies for Multitrait Association Studies
The genetic basis of multiple phenotypes such as gene expression, metabolite levels, or imaging features is often investigated by testing a large collection of hypotheses, probing the existence of association between each of the traits and hundreds of thousands of genotyped variants. Appropriate multiplicity adjustment is crucial to guarantee replicability of findings, and the false discovery r...
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The genetic basis of multiple phenotypes such as gene expression, metabolite levels, or imaging features is often investigated by testing a large collection of hypotheses, probing the existence of association between each of the traits and hundred of thousands of genotyped variants. Appropriate multiplicity adjustment is crucial to guarantee replicability of findings, and False Discovery Rate (...
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ژورنال
عنوان ژورنال: Genetic Epidemiology
سال: 2015
ISSN: 0741-0395,1098-2272
DOI: 10.1002/gepi.21942